PLASMINOGEN, OXIDIZED PHOSPHOLIPIDS AND ATHEROTHROMBOSIS

Oxidized LDL and HDL: antagonists in atherothrombosis.

Increased LDL oxidation is associated with coronary artery disease. The predictive value of circulating oxidized LDL is additive to the Global Risk Assessment Score for cardiovascular risk prediction based on age, gender, total and HDL cholesterol, diabetes, hypertension, and smoking. Circulating oxidized LDL does not originate from extensive metal ion-induced oxidation in the blood but from mi...

Oxidized phospholipids modify plasminogen and apolipoprotein(a): Implications for vascular disease

Whereas the close structural homology between human plasminogen and apolipoprotein(a) has been known for a number of years only recent studies have revealed that both proteins carry linked oxidized phospholipids that may modify the function of these proteins. Future studies should provide a better understanding of oxidized phospholipid adducts and the role played by lipoprotein-associated phosp...

Inflammatory profile of oxidized phospholipids.

Lipid oxidation products and in particular oxidized phospholipids (OxPL) are increasingly recognized as inducers of chronic inflammation characteristic of atherosclerosis. OxPL stimulate production of chemokines and adhesion of monocytes to endothelial cells. However, accumulating data suggest that, in addition to the proatherogenic and proinflammatory effects, OxPL can stimulate antiinflammato...

Biophysical Characterization of Oxidized Phospholipids

A great variety of biochemical processes are either confined to or mediated by cellular membranes constructed around a framework provided by a compositionally heterogeneous and highly dynamic bilayer of phospholipid molecules. Accordingly, the physical properties and molecular organization of these mesoscopic supramolecular assemblies are regarded to represent pivotal determinants of the overal...

Oxidized Phospholipids: Introduction and Biological Significance